34th Mahabaleshwar Seminar on Modern Biology MECHANOSIGNALLING IN CELL AND DEVELOPMENTAL BIOLOGY

Mechanosignalling in Cell and Developmental Biology

This seminar will focus on the relevance of physical connections in the form of cytoskeletal mechanics which helps in sensing and transducing forces from the surface of cells to deep inside. It will bring together researchers working on different aspects of mechanotrasduction in cells and

organisms.

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February 14, 2009

0 8:45-09:45       Registration

10:00-12:30        Introduction : Maithreyi Narasimha (TIFR, Mumbai)

Interactive session: setting up work groups for student participation

Introduction to Mechanosignalling

Cellular scale: G.V.Shivashankar (NCBS-TIFR)

Developmental scale: Maithreyi Narasimha (TIFR)

13:00-14:00 Lunch

14:00-15:30        Membrane organization

Satyajit Mayor (NCBS-TIFR)

15:30-16:00        Tea

16:00 -17:30 Nuclear membrane, pores and nuclear transport
Michael Elbaum (Weizmann Institute, Israel)

18:00 -19:30 Preparation for student presentations

19:30 Dinner at NCBS


February 15, 2009

10:00-11:30      Mechanics for biologists: physical considerations

Gautam Menon (Matscience, Chennai)

11:30-12:00      Tea

12:00-13:00      Invited student presentations

12:00-12:30 Nanoscale organisation of Hedgehog and long range signaling

Neha Vyas (NCBS-TIFR)

12:30-13:00 Physicochemical stresses reveal a prestressed state of the eukaryotic nucleus.
Aprotim Mazumder (NCBS, RRI)

13:00-14:00 Lunch

14:00-15:30 Nuclear mechanics & genome regulation
G. V. Shivashankar (NCBS-TIFR)

15:30-16:00        Tea

16:00-17:30        Mechanical responses of cells and regulation
Pramod Pullarkat (RRI)

18:00 -19:30      Student presentations-1

19:30                 Dinner


February 16, 2009


10:00-11:30       Mechanosensing and the myosin family of molecular motors
Jim Spudich (Stanford University & NCBS-TIFR)

11:30-12:00        Tea


12:00-13:00        Invited student presentations

12:00-12:30        Debanjan Goswami (NCBS-TIFR)

12:30-13:00        Actin dependent lipid architecture on cell membranes
Kripa (RRI, NCBS-TIFR)

13:00-14:00        Lunch

14:00-15:30        Pattern formation in motor protein microtubule mixtures
Gautam Menon (MatScience)

15:30-16:00        Tea

16:00 -17:30       Exploring molecular and macromolecular mechanics using AFM
Srirama Koti (TIFR)

18:00 -19:30        Student presentations-2

19:30                   Dinner at NCBS

February 17, 2009

10:00-11:30        Cytoskeleton-adhesion crosstalk in cell locomotion and mechanotransduction Alexander Bershadsky

11:30-12:00        Tea

12:00-13:00        Invited student presentations

12:00-12:30        Feroz Meeran Hameed (NCBS-TIFR

12:30-13:00        Dymanin-independent membrane internalization: Role of GTPases and dynamic actin polymerization.
Sudha Kumari (NCBS-TIFR)

13:00-13:30        Lunch

14:00-15:30        Membrane/cytoskeletal mechanics-Theoretical considerations
Madan Rao (NCBS-TIFR, RRI)

15:30-16:00        Tea

16:00 -17:30       Emergence of patterned cell behaviour: dynamics and mechanics during development
Maithreyi Narasimha

18:00 -19:30       Student presentations-3

19:30                  Dinner at NCBS


February 18, 2009


10:00-11:30        Forces and force sensing in the course of the development of focal
adhesions

Sasha Bershadsky

11:30-12:00       Tea

12:00-13:00        DNA bending mechanics
Gautam Menon

13:00-14:00       Lunch

14:00-15:30 Selected student presentations- Suspense!
Chair: Sasha Bershadsky

15:30-16:00       Tea

16:00 -18:30     Selected student presentations continued

19:30                Dinner at NCBS

http://www.ncbs.res.in/images//poster.jpgRegistration

All participants are requested to register by submitting a registration fee of Rs.2500. To register, email

maithreyi.narasimha@gmail.com

and bring a Demand draft (payable to Mahabaleshwar seminar).