Bangalore - Milan Workshop

Date : April 6-8, 2009

Venue: National Centre for Biological Sciences, TIFR on April 6^th and 7^th

Jawaharlal Nehru Centre for Advance Scientific Research on April 8th

Program

DAY 1 (6^th April, 2009)

9:15 a.m.

Introductory Talk by K. VijayRaghavan, Director, NCBS: 15 minutes

Introductory Talk by Pier Giuseppe Pelicci, Director, European Institute of Oncology: 10 minutes

Introductory Talk by Marco Foiani, Director, IFOM, FIRC Institute of Molecular Oncology: 10 minutes

Session 1: Model Systems in Disease (Chair: Sudhir Krishna)

Luisa Lanfrancone (IFOM-IEO): RaLP in melanoma genesis and progression

Guruprasad Reddy Sure (NCBS): The complex roles of the JNK signaling scaffold molecule, UNC-16, in regulating mitochondrial distributions in neurons

Rajnish Rao (NCBS): In search of an animal model of PTSD

COFFEE/TEA

11:30 a.m.

Session 2: Genomes and Evolution (Chair: Jayant Udgaonkar)

Dipankar Chatterji (IISc): Towards designing single round transcription in prokaryotes on immobilized templates

Odity Mukherjee (NCBS): Evolutionarily based haplotype analyses of MAPT locus in sporadic taupathies

Uma Ramakrishnan (NCBS): Demographic history and Evolution in the Indian subcontinent: lessons from a comparitive phylogeographic approach for mammals

LUNCH

2:00 p.m.

Session 3: Cell Biology (Chair: Gaiti Hasan)

Sandhya Koushika (NCBS): The stability of the anterograde synaptic vesicle motor,

UNC-104, depends on its ability to bind cargo

Neha Vyas (NCBS): Nanoscale organisation of Hedgehog and long range signaling

Giorgio Scita (IFOM-IEO): Membrane and actin dynamics in the spatial control of signaling during cell migration

Sudha Kumari (NCBS): Post-endocytic sorting of GPI-anchored proteins

COFFEE/TEA

4:00 p.m.

Session 4: Replication and Repair (Chair: Mathew K Mathew)

Marco Foiani (IFOM-IEO): Mechanisms controlling genome integrity during S phase

Namrata Jayant (NCBS): Elucidating substrate specificity of repair enzymes using UV resonance Raman spectroscopy

K. Muniyappa (IISc): Holliday Junction Binding and Processing by Meiosis-Specific Saccharomyces cerevisiae Hop1 Protein

Abani Kanta Naik (IISc.): Mechanism of RAG cleavage on altered DNA structures: a potential threat to genomic stability

Deepak Nair (NCBS): Structural Basis of DNA Lesion bypass by human DNA Polymerase iota

DAY 2 (7^th April, 2009)

9:15 a.m.

Session 1: Signaling and Development (Chair: Maneesha Inamdar)

Mamta Jain (JNCASR): Dissecting the role of rudhira in angiogenesis

Gayatri V (NCBS): Intracellular Ca2+ signaling in the Insulin producing cells of Drosophila

Elisabetta Dejana (IFOM-IEO): The role of Wnt signaling in vascular development

Vani Kulkarrni (JNCASR): Asrij plays a role in hematopoiesis and immunity in Drosophila melanogaster

Pinky Kain (NCBS): Olfactory transduction mechanisms in Drosophila melanogaster

COFFEE/TEA

11:15 p.m.

Session 2: Cancer/Translational Aspects I (Chair: Seema Nanda)

G. Mc Vie (IEO): Translational Research, Challenges and Pitfalls

Devaveena Dey (IISc): Stem Cells and Breast Cancer

Tessy Maliekal (NCBS): Cervical Cancer Spheres and Tumor Properties

Tapas Kundu (JNCASR): Histone Chaperone in Transcription Regulation and Cancer Manifestation: Role of NPM1

Suvasini R (IISc): Differential regulation of DNA damage induced cytotoxicity and cell death by PI3 kinase: Role for p53 and its implications in cancer chemotherapy

LUNCH

2:15 p.m.

Session 3: Chromatin and Signaling (Chair: G. V. Shivashankar)

Arif (JNCASR): Chromatin Modifications Linked to Oral Cancer: a Potential Target for Therapeutics

Pawan Singh (IISc): Mycobacterium leprae RecA intein: a LAGLIDADG homing endonuclease, displays a unique mode of DNA binding and catalysis compared to a canonical LAGLIDADG homing enzyme

Pier Giuseppe Pelicci (IFOM-IEO): Epigenetic treatment of leukemias

Mridula Nambiar (IISc): Molecular Mechanism of Chromosomal Translocations in Lymphoma and Leukemia

COFFEE/TEA

3:45 p.m.

Session 4: Protein and DNA structure and function (Chair: Yamuna Krishnan)

Raghavan Varadarajan (IISc): Design of temperature-sensitive and inactive mutants to understand gene function

Spriha Gogia (NCBS): Studying enzyme active-site interactions using Raman spectroscopy

Jasbir Singh (IISc): Mycobacterium tuberculosis RuvA Induces Two Distinct Types of Structural Distortion between the Homologous and Heterologous Holliday Junctions

Mathew K. Mathew (NCBS): Moving Ions across Biological Membranes

Souvik Modi (NCBS): I-switch: A DNA nanomachine as a cellular reporter

Ruchika Sharma (IISc): RecJ exonuclease and SSB interact physically and functionally

DAY 3 (8^th April, 2009) at JNCASR

9:30 a.m.

Session 1: Cancer/Translational Aspects II (Chair: Tapas Kundu)

Sasikala (NCBS): Regulation of NOTCH1 signaling by deubiquitination

Soumitra Das (IISc): p53 and little brother p47-linking synthesis with protein function

Mohan Kumar (IISc): Proteomic Identification of Haptoglobin as a Glioblastoma Serum Biomarker: Implications in Cancer Chemotherapy

Vaijayanti Gupta (Strand Life Sciences Pvt. Ltd.): Prognostic and signaling pathway based characterization of breast cancer subtypes

COFFEE/TEA

11:30 p.m.

Session 2: Stem Cells and Signaling (Chair: Mitradas Panicker)

Francesco Blasi (IFOM-IEO): Prep1: A novel Tumor Suppressor and Stemness gene

Jeevisha Bajaj (NCBS): Notch signaling in cervical cancer stem-like cells

Pier Giuseppe Pelicci: Regulation of self-renewal in cancer stem cells

Lakshmi P (NCBS): A hierarchical signaling cascade involving Notch and the mTOR – Rictor complex regulates neglect- induced death in mammalian cells