INCF workshop

November 19-21, 2009
NCBS, Bangalore.
 
Overview
This workshop is designed to serve two primary roles: 1. To introduce basic issues and concepts in neuroinformatics and multiscale interactions in biology to Indian students and researchers. 2. To promote the definition of model exchange standards for multiscale systems in biology.

To achieve these goals, the workshop is structured with open sessions where students and other scientists are welcome to attend and participate; and brief closed sessions for each theme where the invited scientists will collate user requirements for each level of multiscale modeling. In addition, the first two days will have public lectures. Finally, the third day of the workshop will be entirely devoted to model exchange definition work among the invitees.
 
Registration

Registration for the workshop is now closed.
Registrants who could not be offered accommodation can search for alternatives at the places suggested here .
 
Motivation:
Biologically detailed modeling has expanded into many different directions, each with specialized numerical tools and unique approaches to representing data and defining models. Multiscale models are becoming increasingly important, as modelers seek to capture crucial biological phenomena that span scales and representations. The figure below illustrates the challenge for multiscale modeling: there are several sets of tools and approaches that tackle specific aspects of neuronal function. Several of these already have model definition languages, others are yet to be so formalized. NeuroML already serves to compose several levels of description (morphology, passive cable properties, channel composition) into neuronal model definitions. This meeting seeks to go the next step, to see how one can generally compose models that span many kinds of mathematical forms and model definitions, and couple this to definitions of experimental manipulations.
 
Figure: Focus Slide
 
Schedule
The first four sessions will begin with an introduction to model specifications. Then there will be two or three 15-min 'user' presentations setting out the specific problems and user needs for a model definition.  The presenters will introduce their system, explain how models are currently defined in it, and give a wish list of things they will soon need from this definition.

Then there will be a closed discussion round to place these requirements in the context of current model specification capabilities, and other projects of the INCF. Each of these brief discussion rounds will aim to put a list of key points on the table for the main discussion session on Saturday.

The Saturday program (which can be extended as needed) is where we hope to pull together the discussion points and come up with specific proposals and responsibilities.
Schedule For Open Sessions
Thursday, 19 November 2009
08:30 AMBreakfast and registration 
09:30 AMWelcome and introductionUpi Bhalla, NCBS, Bangalore
09:35 AMOverview of INCF goals and programmesSten Grillner, Karolinska Institute, Sweden
9:45 AM - 1:00 PMSession 1: Existing specification systemsChair: Erik De Schutter
09:45 AMSummary of related specification efforts and their scopeErik De Schutter, Okinawa Institute for Science and Technology, Japan
10:15 AMSBML, where it's been, where it's goingNicolas Le Novere, European Bioinformatics Institute, UK
10:45 AMA physiome standards-based model publication paradigmDavid Nickerson, University of Auckland, New Zealand
11:15 AMCoffee and discussion: Single-particle to microscopic model specificationLead: Nicolas Le Novere, Jeanette Hellgren Kotaleski
11:45 AMMultiscale models of synaptic plasticity: combining biophysics and biochemistryUpi Bhalla
12:00 PMBridging between neuronal network activity and subcellular signalingJeanette Hellgren Kotaleski, Karolinska Insitute, Sweden
12:15 PMIntegrated membrane potential and reaction-diffusion modeling in STEPSErik De Schutter
12:30 PMDiscussion: Electrical + signalingLead: Erik De Schutter, Upi Bhalla
01:00 PMBreak for lunch 
2:00 PM - 3:30 PMSession 2: Signaling and standardsChair: Sten Grillner
02:00 PMThe process of setting up standards: Round table with Mark Ellisman, Sten Grillner, Erik De Schutter, Nicolas Le Novere, and David Nickerson. 
02:30 PMDevelopmental signalingShyamala Mani, NBRC/IISc
02:45 PMSpatial modeling in VCell - current and plannedJim Schaff, University of Connecticut, USA
03:00 PMTranslation of bio-markers to clinical outcomes – tumor biology based case studyShireen Vali, CellWorks, Bangalore
03:15 PMModeling the role of glial layer in cerebral circulationSrinivas Chakravarthy, IIT Madras
03:30 PMCoffee and discussion: Signaling up and down scalesLead: Mark Ellisman,
David Nickerson, Jim Schaff
04:00 PMRegulation of microtubule length and motility by signalling gradientsChaitanya Athale, IISER
04:15 PMMulti-scale models for cargo transport and cell-scale pattern formationGautam Menon, The Institute of Mathematical Sciences, Chennai
05:00 PMPublic Seminar: Theoretical and functional importance of the shapes of neuronal dendrites and spinesErik De Schutter
06:00 PMHigh tea 
06:30 PMBus to restaurant 
 
Friday, 20 November 2009
08:30 AMBreakfast and discussion: Whitepaper and implementation: setting up teams. 
9:30 AM- 1:00 PMSession 3: Mechanical models; neuronal model standardsChair: Alex Mogilner
09:30 AMMultiscale model of keratocyte lamellipodAlex Mogilner, UC Davis, USA
09:45 AMCoffee and Discussion: Mechanical model specificationsLead: Robert Cannon, Alex Mogilner, Gautam Menon
10:15 AMCurrent and future developments with NeuroMLPadraig Gleeson, University College London, UK
10:30 AMNeuronal and multiscale models with NEURONAndrew Davison, CNRS, Gif sur Yvette, France
10:45 AMFORTRAN, NEURON, and MOOSE: Model matching and standardsSubhasis Ray, NCBS, Bangalore
11:00 AMDiscussion: Space, models, and MLsLead: Andrew Davison, Jim Schaff, Nicolas Le Novere
11:30 AMAnnouncements and organization stuff 
11:45 AMPublic Seminar: Multiscale Imaging of the Nervous System: Where is the Dark MatterMark Ellisman, UC San Diego, USA
01:00 PMBreak for lunch 
2:00 PM – 4:30 PMSession 4: Network multiscalingChairs: Mark Ellisman/ Prasun Roy
02:00 PMDiscussion: Bridging SBML/NeuroML/CellML for signaling plus electrical models?Lead: Jim Schaff, David Nickerson, Erik De Schutter
02:30 PMLarge-scale multiscaling: experiences from the LampreySten Grillner
02:45 PMBrain scale networks in diagnosis and treatment of malignant glioma: towards radiogenomics and programmed therapyPrasun Roy, NBRC, Manesar
03:00 PMBlue Brain Project: Towards large-scale models of neural tissueSean Hill, EPFL, Switzerland
03:15 PMNon-synaptic interaction among neurons during orientation adaptationBasabi Bhaumik, IIT Delhi
03:30 PMSpecification language as user interfaceRobert Cannon, University College, London
04:30 PMCoffee and extended discussion: Interfacing MLsLead: Robert Cannon, Andrew Davison, Padraig Gleeson
05:00 PM - 06:30 PMPublic Lecture: The logics of networks in motion - from ion channels to behaviourSten Grillner
06:45 PM – 08:15 PMCultural Programme 
08:15 PM – 10:00 PMPublic dinner