INCF workshop
November 19-21, 2009
NCBS, Bangalore.
NCBS, Bangalore.
Overview
This workshop is designed to serve two primary roles: 1. To introduce basic issues and concepts in neuroinformatics and multiscale interactions in biology to Indian students and researchers. 2. To promote the definition of model exchange standards for multiscale systems in biology.
To achieve these goals, the workshop is structured with open sessions where students and other scientists are welcome to attend and participate; and brief closed sessions for each theme where the invited scientists will collate user requirements for each level of multiscale modeling. In addition, the first two days will have public lectures. Finally, the third day of the workshop will be entirely devoted to model exchange definition work among the invitees.
This workshop is designed to serve two primary roles: 1. To introduce basic issues and concepts in neuroinformatics and multiscale interactions in biology to Indian students and researchers. 2. To promote the definition of model exchange standards for multiscale systems in biology.
To achieve these goals, the workshop is structured with open sessions where students and other scientists are welcome to attend and participate; and brief closed sessions for each theme where the invited scientists will collate user requirements for each level of multiscale modeling. In addition, the first two days will have public lectures. Finally, the third day of the workshop will be entirely devoted to model exchange definition work among the invitees.
Registration Registration for the workshop is now closed. |
Registrants who could not be offered accommodation can search for alternatives at the places suggested here . |
Motivation:
Biologically detailed modeling has expanded into many different directions, each with specialized numerical tools and unique approaches to representing data and defining models. Multiscale models are becoming increasingly important, as modelers seek to capture crucial biological phenomena that span scales and representations. The figure below illustrates the challenge for multiscale modeling: there are several sets of tools and approaches that tackle specific aspects of neuronal function. Several of these already have model definition languages, others are yet to be so formalized. NeuroML already serves to compose several levels of description (morphology, passive cable properties, channel composition) into neuronal model definitions. This meeting seeks to go the next step, to see how one can generally compose models that span many kinds of mathematical forms and model definitions, and couple this to definitions of experimental manipulations.
Figure: Focus Slide
Schedule
The first four sessions will begin with an introduction to model specifications. Then there will be two or three 15-min 'user' presentations setting out the specific problems and user needs for a model definition. The presenters will introduce their system, explain how models are currently defined in it, and give a wish list of things they will soon need from this definition.
Then there will be a closed discussion round to place these requirements in the context of current model specification capabilities, and other projects of the INCF. Each of these brief discussion rounds will aim to put a list of key points on the table for the main discussion session on Saturday.
The Saturday program (which can be extended as needed) is where we hope to pull together the discussion points and come up with specific proposals and responsibilities.
The first four sessions will begin with an introduction to model specifications. Then there will be two or three 15-min 'user' presentations setting out the specific problems and user needs for a model definition. The presenters will introduce their system, explain how models are currently defined in it, and give a wish list of things they will soon need from this definition.
Then there will be a closed discussion round to place these requirements in the context of current model specification capabilities, and other projects of the INCF. Each of these brief discussion rounds will aim to put a list of key points on the table for the main discussion session on Saturday.
The Saturday program (which can be extended as needed) is where we hope to pull together the discussion points and come up with specific proposals and responsibilities.
Schedule For Open Sessions
Thursday, 19 November 2009 | ||
08:30 AM | Breakfast and registration | |
09:30 AM | Welcome and introduction | Upi Bhalla, NCBS, Bangalore |
09:35 AM | Overview of INCF goals and programmes | Sten Grillner, Karolinska Institute, Sweden |
9:45 AM - 1:00 PM | Session 1: Existing specification systems | Chair: Erik De Schutter |
09:45 AM | Summary of related specification efforts and their scope | Erik De Schutter, Okinawa Institute for Science and Technology, Japan |
10:15 AM | SBML, where it's been, where it's going | Nicolas Le Novere, European Bioinformatics Institute, UK |
10:45 AM | A physiome standards-based model publication paradigm | David Nickerson, University of Auckland, New Zealand |
11:15 AM | Coffee and discussion: Single-particle to microscopic model specification | Lead: Nicolas Le Novere, Jeanette Hellgren Kotaleski |
11:45 AM | Multiscale models of synaptic plasticity: combining biophysics and biochemistry | Upi Bhalla |
12:00 PM | Bridging between neuronal network activity and subcellular signaling | Jeanette Hellgren Kotaleski, Karolinska Insitute, Sweden |
12:15 PM | Integrated membrane potential and reaction-diffusion modeling in STEPS | Erik De Schutter |
12:30 PM | Discussion: Electrical + signaling | Lead: Erik De Schutter, Upi Bhalla |
01:00 PM | Break for lunch | |
2:00 PM - 3:30 PM | Session 2: Signaling and standards | Chair: Sten Grillner |
02:00 PM | The process of setting up standards: Round table with Mark Ellisman, Sten Grillner, Erik De Schutter, Nicolas Le Novere, and David Nickerson. | |
02:30 PM | Developmental signaling | Shyamala Mani, NBRC/IISc |
02:45 PM | Spatial modeling in VCell - current and planned | Jim Schaff, University of Connecticut, USA |
03:00 PM | Translation of bio-markers to clinical outcomes – tumor biology based case study | Shireen Vali, CellWorks, Bangalore |
03:15 PM | Modeling the role of glial layer in cerebral circulation | Srinivas Chakravarthy, IIT Madras |
03:30 PM | Coffee and discussion: Signaling up and down scales | Lead: Mark Ellisman, David Nickerson, Jim Schaff |
04:00 PM | Regulation of microtubule length and motility by signalling gradients | Chaitanya Athale, IISER |
04:15 PM | Multi-scale models for cargo transport and cell-scale pattern formation | Gautam Menon, The Institute of Mathematical Sciences, Chennai |
05:00 PM | Public Seminar: Theoretical and functional importance of the shapes of neuronal dendrites and spines | Erik De Schutter |
06:00 PM | High tea | |
06:30 PM | Bus to restaurant | |
Friday, 20 November 2009 | ||
08:30 AM | Breakfast and discussion: Whitepaper and implementation: setting up teams. | |
9:30 AM- 1:00 PM | Session 3: Mechanical models; neuronal model standards | Chair: Alex Mogilner |
09:30 AM | Multiscale model of keratocyte lamellipod | Alex Mogilner, UC Davis, USA |
09:45 AM | Coffee and Discussion: Mechanical model specifications | Lead: Robert Cannon, Alex Mogilner, Gautam Menon |
10:15 AM | Current and future developments with NeuroML | Padraig Gleeson, University College London, UK |
10:30 AM | Neuronal and multiscale models with NEURON | Andrew Davison, CNRS, Gif sur Yvette, France |
10:45 AM | FORTRAN, NEURON, and MOOSE: Model matching and standards | Subhasis Ray, NCBS, Bangalore |
11:00 AM | Discussion: Space, models, and MLs | Lead: Andrew Davison, Jim Schaff, Nicolas Le Novere |
11:30 AM | Announcements and organization stuff | |
11:45 AM | Public Seminar: Multiscale Imaging of the Nervous System: Where is the Dark Matter | Mark Ellisman, UC San Diego, USA |
01:00 PM | Break for lunch | |
2:00 PM – 4:30 PM | Session 4: Network multiscaling | Chairs: Mark Ellisman/ Prasun Roy |
02:00 PM | Discussion: Bridging SBML/NeuroML/CellML for signaling plus electrical models? | Lead: Jim Schaff, David Nickerson, Erik De Schutter |
02:30 PM | Large-scale multiscaling: experiences from the Lamprey | Sten Grillner |
02:45 PM | Brain scale networks in diagnosis and treatment of malignant glioma: towards radiogenomics and programmed therapy | Prasun Roy, NBRC, Manesar |
03:00 PM | Blue Brain Project: Towards large-scale models of neural tissue | Sean Hill, EPFL, Switzerland |
03:15 PM | Non-synaptic interaction among neurons during orientation adaptation | Basabi Bhaumik, IIT Delhi |
03:30 PM | Specification language as user interface | Robert Cannon, University College, London |
04:30 PM | Coffee and extended discussion: Interfacing MLs | Lead: Robert Cannon, Andrew Davison, Padraig Gleeson |
05:00 PM - 06:30 PM | Public Lecture: The logics of networks in motion - from ion channels to behaviour | Sten Grillner |
06:45 PM – 08:15 PM | Cultural Programme | |
08:15 PM – 10:00 PM | Public dinner |